How spec sheets write it
The most common ways bicycle spec sheets name it, by number of mentions.
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Shimano ST-R221 Precision Integrated Brake/Shifting
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Shimano ST-R221-R Precision Integrated Brake and Shifting
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Shimano R221, EZ Fire
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Shimano R221
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Shimano ST-R221 EZ Fire - Black
Bicycles
Published bicycles that use it, newest model years first.